Fasting blood glucose 7.5mmol\x2fL, 7.1 mmol\x2fL two hours after meal, why?

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Fasting blood glucose 7.5mmol\x2fL, 7.1 mmol\x2fL two hours after meal, why?

2018-11-02 10:25:41 107 ℃

Fasting blood glucose 7.5mmol/L, 7.1 mmol/L two hours after meal, why?

For more health information, please pay attention to "Dr. Li Qing"

You There is no problem with the diagnosis of diabetes. Your blood sugar is characterized by high fasting blood sugar and normal blood sugar 2 hours after a meal, mainly due to insulin secretion.

The secretion of insulin in normal humans can be divided into basal insulin secretion and insulin secretion after meals. These two parts of insulin secretion account for about 50% each.

Basic insulin refers to insulin secretion in fasting state, independent of eating, its main physiological role is to inhibit the decomposition of liver glycogen and gluconeogenesis (protein, fat conversion into Sugar is called gluconeogenesis, to reduce the production of glucose and to maintain the use of glucose in surrounding tissues and organs (such as the brain, muscles, etc.), so that blood sugar in the fasting state is maintained at a normal level.

Mealtime insulin is insulin that is secreted along with meals. Normal people 8-10 minutes after the meal, plasma insulin levels began to rise, peaked at 30 to 45 minutes, and then decreased with the decline in blood glucose levels, and returned to the basal level 90 to 120 minutes after the meal. Normal people have about 6-8 units of insulin after meal. The main role of insulin during meal is to inhibit the production of endogenous glucose in the liver and to control the magnitude and duration of postprandial blood glucose elevation. Through this mechanism of action, blood glucose is controlled at a level close to the fasting state at any time.

If the basal insulin is insufficiently secreted and the insulin secretion is normal during meals, it is characterized by high fasting blood glucose and normal postprandial blood glucose. You fall into this situation.

Clinically, supplemental basal insulin with nighttime injection of long-acting insulin such as insulin glargine, insulin detemir, etc. once a day; supplemented with pre-meal injections such as short-acting insulin such as insulin aspart Insulin, injected before each meal.

So, you should take oral metformin treatment in this case. If the effect is not satisfactory, you can use long-acting insulin at night on the basis of metformin.