Female infertility: care for women with polycystic ovary syndrome

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Female infertility: care for women with polycystic ovary syndrome

2016-07-21 03:16:31 408 ℃

Polycystic ovary syndrome (polycystic ovary, syndrome, PCOS) is the most common in women of childbearing age, endocrine and metabolic disordersChaosDisease is the main cause of infertility. The disease lead to reproductive failure is the direct cause of anovulation and also lead to patients with glucose and lipid metabolism and increase the risk of diabetes, cardiovascular disease, risk, and increase the abortion, gestational diabetes, gestational period hypertension and the risk of fetal malformations. Before the treatment of adjuvant fertility, according to the patient's endocrine and metabolic state, given the appropriate pretreatment and adjuvant therapy, can improve the probability of pregnancy.

At present, it is believed that the obesity, especially central obesity), hyperandrogenism and insulin resistance is three interdependent and mutually promoting factors, can lead to infertility due to anovulation. The hormone disorder caused by obesity can lead to abnormal biochemical indexes and ovarian dysfunction. Both overweight and obesity significantly affect the quality of eggs, so as to reduce the success rate of IVF treatment, while increasing the probability of abortion. The development of the sinus and the formation of the follicular phase and the differentiation of the granulosa cells in the sinus of Kaohsiung are stopped by the development of the hormone in the sinus, which leads to the disorder of the ovarian follicle maturation. Insulin resistance makes the follicles mature and blocked, can not ovulation, thus affecting fertility. Therefore, the auxiliary treatment of polycystic ovary syndrome is mainly aimed at the three aspects of the body conditioning.

Adjuvant therapy includes the following aspects:


Weight loss: weight loss is the treatment of polycystic ovary syndrome must be the program, the current consensus that increased exercise and diet control, such as lifestyle adjustment is the best way. Studies show that patients with weight loss of 15% ~ 7%, you can change the insulin resistance, and impaired glucose tolerance improved, some patients can resume spontaneous menstruation, and even ovulation pregnancy.<1Two3>


Reduce androgen therapy: Patients with Kaohsiung hormone therapy is preferred


- Three5, Yasmin and other drugs for lowering androgen treatment could significantly reduce serum androgen levels, and improve and promote the ovulation effect.3

Insulin resistance treatment: about 50% ~ 70% of PCOS patients with insulin resistance, treatment of insulin resistance is an important part of the treatment, which is the most widely used metformin. Metformin improves glucose metabolism and lipid metabolism by increasing insulin sensitivity and the use of sugar to reduce postprandial insulin secretion. International studies have acknowledged that metformin is not known to be a human embryo or a lethal effect on the embryo, and it is safe to use during pregnancy.

This article reprinted from "the second hospital of Lanzhou and female reproductive health management center public No.