"Science" heavy pounds: EB virus is actually the incentive of "no cancer"?

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"Science" heavy pounds: EB virus is actually the incentive of "no cancer"?

2022-01-19 06:05:44 60 ℃

Multiple sclerosis (MS) is the central nervous system of unknown etiology chronic inflammatory demyelinating disease. Brain and spinal cord demyelination is an immune-mediated process, it may be caused by a viral infection. In the hypothetical risk factors, the most likely it is the Epstein-Barr virus (EBV). EBV is a human herpesvirus infection throughout the life cycle of the host in a latent form in persistent B lymphocytes. However, there is still a lack of sufficient evidence to prove a causal relationship between the contact EB virus and multiple sclerosis.

Report 2022 Nian 1 13, an article entitled Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis is published in Science. By 955 cases with multiple sclerosis American servicemen tracking study, the researchers draw an important conclusion: always EB virus seronegative people, EB virus seropositive persons risk of the occurrence of MS compared to an increase of 32.4 times.

Source: Science

The presence of specific association between EB virus and multiple sclerosis

The researchers recorded a total of 955 cases of servicemen multiple sclerosis patients. For each case of multiple sclerosis, researchers collected prior to the date of onset of multiple sclerosis which three serum samples (first available, the last one acquired prior to onset of the disease, the middle one). By screening of the cases were matched controls, a total of 801 cases of 1566 cases of multiple sclerosis patients and control samples may be used to evaluate the EB virus infection.

In 801 cases of multiple sclerosis cases, only one patient tested negative EB virus sample collection time before the onset of multiple sclerosis year. In the first serum sample is detected (i.e., baseline check) of 35 MS patients and 107 controls were negative EB virus. Of particular note is that 35 cases of MS patients EB virus-negative, except one, were infected with EB virus to rest during follow-up, and before all the pathogenesis of MS sera were converted to seropositive.

Hardened case group and control group samples, the researchers found by comparing multiple follow-up period, set in multiple sclerosis patients, EB virus-positive conversion of 97% serum. However, in the control sample group, seroprevalence rate of only 57% conversion. By estimation, always EB virus seronegative people, EB virus seropositivity converters risk of occurrence of multiple sclerosis compared to an increase of 32.4 times.

EB virus first occurred with multiple sclerosis

Like other nervous system diseases, multiple sclerosis pathological mechanism may begin several years before the first symptoms appear. Whether there is some kind of temporal relationship between EB virus infection and the onset of multiple sclerosis? To solve this problem, researchers used a single molecule ultrasensitive assay measuring the serum concentration of neurofilament light chain (sNfL) a. sNfL denaturation sensitive axons (although not a disease-specific) comprising one biomarker in progress.

The researchers found that those who continue to develop and EB virus-negative for the individual multiple sclerosis, sNfL level similar to non-multiple sclerosis in the control group before and after EBV infection, but increased after EBV infection. Therefore, in the later development of multiple sclerosis in individuals, there is no sign of axonal degeneration before the EB virus seroconversion, suggesting that the EB virus infection not only before the onset of symptoms, and pathology in multiple sclerosis before the first detectable mechanism.

Whether other viral infections can lead to the occurrence of multiple sclerosis it? The researchers randomly selected 30 cases of MS patients and 30 matched controls, and serum samples were collected shortly before and after the onset of symptoms, based T7 phage display immunoprecipitation and sequencing the antibody response against the virus to conduct a comprehensive search. Virus scan can detect antibodies against all fully linear peptide known to infect humans encoded in the viral genome.

The results showed that in addition to the EB virus, cases and controls were similar antibody response to whole virus peptide in both time points. This is nothing to indicate that pre-clinical and early-stage multiple sclerosis and immune disorders affect susceptibility to infection. It also provides evidence for the specific association between EB virus and MS.

According to reports in August 2020, The Lancet Regional Health, the incidence of multiple sclerosis in China is 0.235 / 10 million annually for children 0.055 / 10 million adults 0.288 / 10 million. As a rare disease, although the incidence rate is not high, but the patient has brought great pain. Currently there is no effective cure for multiple sclerosis therapy, mainly in the clinical treatment of disease amended (DMT) based. However, as of now, the domestic correction therapy for multiple sclerosis is still very scarce. Xiao Bian called home at the same time to develop common innovative drugs, rare diseases should also be concerned about the treatment of drug development, drug research and development of Pratt & Whitney public.