Reduce urinary protein, protect the "best combination" of renal function, and introduce new gospel

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Reduce urinary protein, protect the "best combination" of renal function, and introduce new gospel

2022-01-23 18:06:39 59 ℃

For the Puli / Sassan drug, kidney disease should be no stranger. Since 1981, the urine protein has been reduced, and the kidney function has repeatedly built a strong sense, and has become a kind of drug for the most successful drug application in Nephrology in the past 40 years. About 50% of kidney friends are taking.

However, such drugs have a role - raised blood potassium, to some extent, to a penetration, especially those with renal failure of creatinine more than 265 μmol / L (high potaemia risk).

For a long time, nephrology faced a dilemma:

The only type of kidney medicine, neutronless patients are not convenient

The situation is quite embarrassing ...

Can't you use it? It can also be used, just need to closely monitor the electrolyte (mainly blood potassium), and discover high potaemia.

Of course, most renal physicians have been directly selected. After all, severe high blood potassium will die (heart stop).

Is this problem solved? Solved, but not completely solved. It can take blood potash to solve high potassium problems; but at the same time, it will bring new side effects - demolition of the wall to make up the West Wall.

Recently, it seems to have a better high potassium solution, and these two perfectations: "Puli / Shantan + Columns".

Recently, EUR HEART J issued the latest post-analysis of the Crender test, which shows:

Koglie net, can reduce the risk of high blood potassium drugs in Puli / Sassan

The Crender Test is a test of Koglie net treatment of diabetes and chronic kidney disease, incorporating 4401 patients. All kidney prouds accepted the treatment of Puli / Sassan before entering the group.

research shows:

Compared with the placebo group, the rate of high potaemia in the Cagliji group was reduced by 23%.

Insufficient in the United States is that the test drug is a card, the indications are slightly narrow, only for kidney disease with diabetes. Instead of Ginger (available for nephropathy, various nephritis, kidney, etc.) without diabetes. Although according to the push effect, theoretically, the net can also reduce the risk of high blood potassium, but after all, there is no hammer, so I just said that I have a better high potassium solution.

Use the column net, whether it is also a demolition of the wall to supplement the Western wall?

Not like this, because the 2020 DAPA-CKD trial has been confirmed that the lane drug itself has kidney therapeutic effect, which can reduce urinary protein and protect the kidney function. Even if it is not considered, patients with chronic kidney disease should also be actively considered.

The urinary protein effect of the column drug is comparable to the Puli / Shatan drug, and the kidney function is 2 times.

Studies have shown that the urinary protein effects can be superimposed. Puli / Sassan drug uses a sufficient dose, an average reduction of 50% of urine protein; applied columns on the basis of Pli / Sassan drug, can reduce 50% on the basis of 50% urine protein .

In terms of renal function protection, the purified drugs are better than the Puli / Shatan drug, and the rate of lowering the rate of glomerular filtration is 4 times.

This is not to disassemble the wall to make up the Western wall, but in the case of the use of the collar drug, it has found a new benefit.

"Puli / Shantan + Columns", the two effects are superimposed, and the high potassium side effects have become the best combination of chronic kidney disease basis.