Squeezing cells can accelerate division and growth

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Squeezing cells can accelerate division and growth

2022-06-23 18:23:01 8 ℃

The closer the distance between people, the more opportunities to exchange ideas and information. The distance between the cells is close, and there will also be a "chemical reaction". A latest study at MIT and Children's Hospital of Boston found that physical squeezing cells and its internal content can make the growth and division of cells exceeding normal levels. This research has opened up new ideas for organizing and regenerative medical organ transplantation. Related papers have recently published online in "Cell Stem Cell" magazine.

Although extruded organisms make it sound violation of common sense, the research team explained that the role of squeezing is to "screw out" the water in the cells, so that the protein and other cell components are also piled together closer. At the same time, protein can gather along specific signal pathways to help cells maintain stem cell state, so cells can grow and split quickly.

Guo Ming (transliteration), associate professor of mechanical engineering at Massachusetts Institute of Technology, and his colleagues have cultivated human colon organs in the diner, and injecting polymers into the diner to "squeeze" organs by injecting into a diner. The injection of the polymer increases the osmotic pressure around each organ, forcing the water to flow out of the cells. Researchers have observed that the specific protein participating in the activation of the WNT pathway is tightly stacked together, which is more likely to activate the signal pathway and its regulating growth genes.

The results show that those crushed organs grow larger and faster than the unwanted organs, and there are more stem cells on the surface. This proves that squeezing does affect the growth of organs, and the behavior of cells may change due to the amount of moisture it contains.

Guo Ming said that as long as the cells simply squeeze the cells and promote its "stem cellization", it can guide cells to quickly cultivate organs, such as artificial intestines and colon. The channels can also be applied to the organ transplantation of recycled medicine.

In the future, researchers will continue to explore the "squeeze" of cells and use it as a way to accelerate the growth of organs. They may also use these artificial organs to test new personalized drugs.