To what extent should cholesterol take medicine?

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To what extent should cholesterol take medicine?

2022-06-24 06:09:05 5 ℃

How do he eat? The pharmacist teaches you to eat

The normal upper limit of low-density lipoprotein cholesterol (LDL-C) given on the medical examination form is 3.37mmol/L. So do you have to take medicine after exceeding the standard?

If you need to take medicine, how much does the blood lipids drop after taking the medicine? Why do some information say to 2.6 mmol/L, and some information say to 1.8 mmol/L? Which one is right?

1. Weight loss cannot reduce blood lipids

Hypertension, hyperglycemia, and hyperlipidemia are called "three highs". We know that the harm of hypertension and high blood sugar will also be treated with medication.

However, many people do not understand high blood lipids. Some people think that blood lipids are fat in blood, which is similar to the fat on the body. It can be reduced by diet and exercise.

These people think wrong. Although blood lipids are also fat, the method of weight loss cannot effectively reduce blood lipids. Because of the cholesterol in the human body, dietary intake accounts for only 20%to 30%, and 70%to 80%of them are synthesized by themselves.

And when cholesterol intake in diet decreases, the number of compound cholesterol increases accordingly.

In other words, the impact of diet control and exercise regulation on blood lipids is very limited. Many people with normal weight or thinner may also have hyperlipidemia.

Second, the effect of hyperlipidemia on the body

Hyperlipidemia is very harmful to the human body, and the level of cholesterol in blood lipids is closely related to the formation of atherosclerosis.

The most important indicator is LDL-C, because LDL-C is the main "raw material" for forming porridge hardened plaques.

When the level of LDL-C in the blood rises, the LDL-C will enter the endometrium to form plaques; and when the level of LDL-C in the blood decreases, the LDL-C can flow back from the blood from the endometrium.

However, most of the LDL-C entering the endometrium will be devoured by macrophages, which will eventually form foam cells deposited in the endometrium.

The LDL-C that forms foam cells can no longer flow back to the blood, so once the atherosclerotic plaque is formed, it cannot be completely removed.

The atherosclerosis is the main cause of cardiovascular and cerebrovascular diseases such as coronary heart disease, myocardial infarction, and cerebral infarction. These diseases will seriously affect people's lives and health, so we must actively control LDL-C to avoid its ascension high.

Third, to what extent should cholesterol take medicine

The blood lipid examination on the medical examination form is less than 3.37mmol/L for LDL-C. It should be noted that this is just a reference standard for healthy people without other diseases.

People with good health, if there are not many blood lipids, do not have to rush to take medicine. Generally speaking, the standard for health people is LDL-C higher than 4.9mmol/L.

For other people with chronic diseases, you cannot refer to the 3.37mmol/L standard. For people with basic diseases such as hypertension and diabetes, if atherosclerosis has been detected, but cardiovascular and cerebrovascular diseases have not yet occurred, the control standard for LDL-C is below 2.6mmol/L.

If you have coronary heart disease, or people who have had diseases such as cerebral infarction and myocardial infarction, the control standard of the LDL-C is below 1.8mmol/L. If the degree of danger is high, the LDL-C can be further controlled below 1.4 mmol/L.

Now it is considered that the lower the level of LDL-C, the stronger the protection of cardiovascular and cerebrovascular. In the relevant test, some subjects reduced LDL-C to about 0.7mmol/L. There were no adverse events. One saying is that if your plaque is not reversed, it means that your LDL-C is not low enough.

The control of LDL-C is mainly based on statins, because statins can not only reduce LDL-C, but also stabilize plaques and prevent collapse of plaques. If the use of Jetin-like drugs alone cannot make the LDL-C compliance, you can consider combining Jetine with cholesterol absorption inhibitors and PCSK9 inhibitors.

Fourth, summary

To sum up, the standards of LDL-C control are different in different physical states, so the standards for medication are different.

For healthy people who do not have chronic diseases, LDL-C has a mild exceeding the standard. Although the regulation of diet and exercise has limited impact on blood lipids, a healthy lifestyle has a positive prevention effect on all "three high" chronic diseases, and should be adhered to for a long time.

If the blood lipid rises more or have other chronic diseases, you need to use drugs to control blood lipids under the guidance of a doctor.

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Source of this article: pharmacist Huazi

Author of this article: Huazi Pharmacist

Editor in charge: Peng Jianping Zhang Li

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